Endometriosis is a common gynecologic condition affecting 10% of people with uteruses and up to 70% of those with chronic pelvic pain. Appendiceal endometriosis is common and pre-operative diagnosis is challenging. This video reviews prevalence of appendiceal endometriosis, highlights important anatomical landmarks for appendectomy and demonstrates a novel technique for laparoscopic appendectomy using a CO2 Laser at the time of surgical management of endometriosis. The laser appendectomy approach is reviewed in four steps, addressing preoperative and intraoperative considerations. This video can be used as a reference for gynecologists when performing appendectomy at the time of hysterectomy or diagnostic laparoscopy for chronic pelvic pain.